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CMS Audit Risk · Data Analysis

82% of CMS Research Principal Investigators Also Received a General Payment in 2025

Research and general payment relationships increasingly overlap, and a growing share is with the same company. Here's what the data shows, and doesn't.

Published September 19, 2026 · qordata Compliance Intelligence

Of the 31,167 physicians who served as a Research Payment Principal Investigator (PI) in CMS Open Payments data in 2025, 25,596 also received a General Payment, consulting, speaking, or other non-research compensation, from a manufacturer that same year. That's 82.1% of research PIs, up from 79.6% in 2023.

Narrow it to the same manufacturer, and the share of research relationships that also carry a general payment from that exact company rose from 28.7% in 2023 to 31.0% in 2025. Roughly 3 in 10 industry-funded research relationships now run alongside a non-research financial relationship with the same company, and the share is climbing.

Key takeaways
  • 82.1% of 2025 research PIs also received a general payment from any manufacturer, up from 79.6% in 2023.
  • 31.0% of research relationships carried a general payment from the exact same manufacturer in 2025, up from 28.7% in 2023.
  • This is a monitoring indicator, not evidence of misclassification. CMS treats General Payment and Research Payment documentation as separate request categories.
  • Research Payment records missing a ClinicalTrials.gov ID and study name run 3-5x higher in average dollar amount, concentrated entirely in preclinical research.

What the overlap actually shows

This is the closest this dataset gets to a structuring question, and it's worth being direct about what it does and doesn't show. Nothing here proves a research payment was mislabeled. What it shows is how often a research relationship and a general payment relationship exist for the same physician, and how often it's with the same company.

Research PI overlap with General Payments, 2023-2025 (purple: any manufacturer, gold: same manufacturer)
0%20%40%60%80%202320242025 82.1%31.0% Program year Share of research PIs (%)
Source: CMS Open Payments General Payment and Research Payment files, joined on Covered_Recipient_NPI (General) and Principal_Investigator_1_NPI (Research), program years 2023-2025.
Program yearResearch PIsAlso received a General PaymentOverlap
202331,54425,09979.6%
202431,59725,54780.9%
202531,16725,59682.1%

Both lines move the same direction. The overall overlap rate and the same-payer overlap rate have both climbed in each of the three years measured.

A second signal: documentation completeness

Research Payment records missing both a ClinicalTrials.gov identifier and a study name show meaningfully higher average payment amounts in every year measured, 5.0x higher in 2023, 3.0x higher in 2025. That's a documentation-completeness pattern, not proof of anything improper. Legitimate observational and proprietary-protocol research can lack a public trial registration.

Splitting the gap out by research type sharpens it. Every non-preclinical research payment record in 2023, 2024, and 2025, essentially anything tied to a named clinical study, carries a study name on file. The gap lives entirely inside preclinical research, where undocumented payments still average roughly 2-4x more than fully documented ones each year ($29,739 vs. $7,847 in 2023; $27,382 vs. $10,138 in 2025).

Why this matters for your audit risk

CMS's own audit guidance, Open Payments: Audit Best Practices 2026, lists documentation related to General Payment records, documentation related to Research Payment records, and agreements for consulting fees, speaker or educational fees as separate categories an auditor can request.

Why segregation matters: If your general-ledger and Research Payment records show heavy same-payer overlap, expect a reviewer, internal or external, to check whether the two payment streams are properly segregated and independently substantiated, not commingled.

What to check in your own data

  1. Calculate your own overlap rate. What share of your research PIs also received a general payment from your company the same year, against the 2025 national benchmark of 82.1% overall and 31.0% same-payer.
  2. Check documentation completeness. What share of your Research Payment records are missing both a ClinicalTrials.gov ID and a study name.
  3. Confirm segregation. Verify that research and general payment agreements for the same Healthcare Professional (HCP) are documented and substantiated separately, with independent supporting files.
  4. Flag preclinical records specifically. The documentation gap concentrates almost entirely in preclinical research; non-preclinical records tied to a named study are consistently well-documented.
Related reading
Reading Principal-Investigator Totals Correctly
Related
CMS Open Payments Data Corrections Jumped Almost 179x in One Year
See how the overlap benchmark fits with the other two signals
The full CMS Audit Risk Report walks through the removed/deleted surge, physician and hospital payment spikes, and research payment overlap, each benchmarked against three years of national Open Payments data, with a checklist for what to review in your own reporting.
Download the CMS Audit Risk Report

Frequently asked questions

What share of CMS research principal investigators also receive a general payment?

82.1% in 2025, up from 79.6% in 2023 and 80.9% in 2024. Of the 31,167 physicians who served as a Research Payment Principal Investigator in 2025, 25,596 also received a General Payment, such as consulting, speaking, or other non-research compensation, from any manufacturer that same year.

What does same-payer overlap mean in CMS Open Payments data?

It's the narrower share of research relationships where the Principal Investigator also received a General Payment from that exact same manufacturer, not just any manufacturer, in the same year. That share rose from 28.7% in 2023 to 31.0% in 2025, meaning roughly 3 in 10 industry-funded research relationships now run alongside a non-research financial relationship with the same company.

Does research and general payment overlap mean a payment was misclassified?

No. This is a monitoring indicator, not evidence that any specific payment was misclassified. A physician can legitimately run industry-funded research and also serve as a paid consultant for the same company. What it means is that a growing share of research relationships also carry a general payment stream that needs to stay documented and segregated.

How can a compliance team check its own research payment documentation?

Check what share of your Research Payment records are missing both a ClinicalTrials.gov identifier and a study name, then check what share of your research PIs also received a general payment from your company the same year. qordata's CMS Audit Risk Report includes the full methodology and national benchmarks, and qordata's CARE team can run this check against your own data directly.

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